It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. What helps nausea from plaquenil Hydroxychloroquine plaquenil and ibuprofen Taking plaquenil and sun exposure Aralen 250 mg dosage How is mixed connective tissue disease treated? The goal of treatment for MCTD is to suppress the immune-related inflammation of tissues. This is a very similar approach to the treatment of lupus. Often corticosteroids such as prednisone are prescribed to accomplish this. Cases that are less severe can often be treated with nonsteroidal anti-inflammatory drugs NSAIDs, hydroxychoroquine such as Plaquenil and lower doses of corticosteroids. MCTD Support Group. Mixed connective tissue disease MCTD or Sharp's syndrome is a human autoimmune disease in which the immune system attacks the body. MCTD combines features of polymyositis, systemic lupus erythematosus, and systemic scleroderma and is thus considered an overlap syndrome. Jan 04, 2018 Mixed connective tissue disease MCTD is a rare autoimmune disorder. It’s sometimes called an overlap disease because many of its symptoms overlap with those of other connective tissue disorders, such as lupus, scleroderma, and polymyositis. Some cases of MCTD also share symptoms with rheumatoid arthritis. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Mctd and plaquenil Treating Lupus with Anti-Malarial Drugs Johns Hopkins., Plaquenil and tinnitus DailyStrength Chloroquine and primaquine us militaryPepto bismol and plaquenil interaction Mixed connective-tissue disease MCTD was first recognized by Sharp and colleagues 1972 in a group of patients with overlapping clinical features of systemic lupus erythematosus SLE, scleroderma, and myositis, with the presence of a distinctive antibody against what now is known to be U1-ribonucleoprotein RNP. Mixed Connective-Tissue Disease Medication Nonsteroidal anti.. Mixed Connective Tissue Disease Symptoms, Causes, and Treatment. Newly diagnosed with Mixed Connective Tissue Disease.. I was diagnosed with MCTD 10 years ago. Since then i have tried Plaquenil, Prednisone, Methotrexate, Humira Injections and now currently Imuran 200 mg daily. I also have a sleep disorder Restless Leg Syndrome so between the two it is not fun. I have been taking plaquenil for uctd for about 6 years or so. Can't live without it. Supposed to take couple months to kick in but worked for me within 2 days. If I miss a dose, I feel it a day and a half later- my legs like lead, really lousy, etc. I am extremely sensitive and responsive to it. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so.