Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine in diabetes Chloroquine phosphate adverse effects How common is diarrhea with plaquenil Plaquenil and mouth sores Toxicity causes a parafoveal or extramacular loss of photoreceptors and the retinal pigment epithelium layer RPE. End stage maculopathy causes a bull’s eye pattern of RPE loss as well as possible cystoid macular edema, loss of central and peripheral vision as well as night vision. When vision is impacted it can include paracentral scotoma early decreased color vision early reduced acuity late reduced peripheral vision late reduced night vision late Signs. The classic sign of hydroxychloroquine retinopathy is bilateral “bull’s-eye” appearance of the macula due to disruption of the retinal pigmented epithelium. When allowed to advance, hydroxychloroquine retinal toxicity leads to loss of up to three visual functions acuity, peripheral vision and night vision. Signs. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil retinal toxicity night vision Has anyone experienced plaquenil toxicity with damage to eyes?, Plaquenil Toxicity - Why chloroquineChloroquine vs chloroquinineMethotrexate hydroxychloroquine sulfasalazineBenefits of using plaquenil The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience permanent vision loss resulting from hydroxychloroquine retinopathy due to improper dosing of the drug and improper screening. Despite Plaquenil dosing recommendations, retinal toxicity.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Long-Term Side Effects of Plaquenil for Rheumatoid.. The issues are reading, color and night vision. Patient 2 69 year old male presents with a history of long term plaquenil use. Diagnosed with RA at age 19 now has almost no use of his hands. Has had 10 surgeries mostly joint replacements, stopped all drugs last year after a life threatening infection now starting back on therapy. Plaquenil is an extremely safe medication but retinal and corneal side effects are possible. Unfortunately, the retinal side effects are largely irreversible and can lead to vision loss. So, it is critical to detect early retinal toxicity in the hopes of limiting the extent of visual loss. Sep 15, 2014 Advanced hydroxy- chloroquine toxicity is seen as damage and atrophy of the retina and its supporting layer, the retinal pigment epithelium, with resultant loss of central, peripheral, and/or night vision. Therefore, screening to detect early signs of retinal toxicity is crucial to try and help patients preserve vision.