To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation. Why is hydroxychloroquine prescribed Plaquenil dosing ideal body weight How much does generic plaquenil cost SD-OCT can show signs of early HCQ retinopathy before unmistakable parafoveal EZ disruption develops, and these signs may assist in earlier detection of HCQ toxicity. Early detection is critical because both structural and functional progression may occur after the drug is discontinued. A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. High-speed ultra–high-resolution optical coherence tomography OCT shows severe loss of the photoreceptor inner segment/outer segment junction layer, thinned outer nuclear layer, and perifoveal hyperscattering as well as increased penetration of the optical coherence tomography beams into the choroid. Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center. Plaquenil retinopathy oct Retinal Physician - Hydroxychloroquine Maculopathy An., Hydroxychloroquine Plaquenil Toxicity and. Can you use plaquenil if allergic to quinine Background/Aims Hydroxychloroquine HCQ retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography OCT abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field HVF testing. Methods Data from. Early hydroxychloroquine retinopathy optical coherence.. CLINICAL SCIENCES High-Speed Ultra–High. - oct-. Expanded spectral domain-OCT findings in the early.. Hydroxychloroquine Retinopathy with SD-OCT Changes and Minimal Fundus Changes The images shown here refer to the same case as "Hydroxychloroquine Retinopathy with Minimal Fundus Changes". This 68 year old woman with systemic lupus erythematosus had been on hydroxychloroquine at a dosage of 400 mg/d 6.52 mg/kg/d for eight years. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Spectral Domain Optical Coherence Tomography SD-OCT shows that there is early thinning of outer retinal layers, typically with loss of the parafoveal photoreceptor inner segment/outer segment IS/OS junction and central foveal sparing. There is preservation of the RPE and external limiting membrane.