Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Ocular toxicity of hydroxychloroquine Chloroquine storage in retina How does hydroxychloroquine kill malaria Plaquenil and drinking alcohol Lipusu is the liposome of paclitaxel, it overcomes the characteristics of paclitaxel, which is difficult to dissolve in water, and has a lower adverse reaction7. Nedaplatin is a second generation platinum drug with lower gastrointestinal toxicity and neurotoxicity8. This study aims to examine the effect of paclitaxel Prophylactic use of liposomal chloroquine increases the efficacy of fluconazole in mice infected with less-susceptible strains of C. neoformans to fluconazole. Mice were pre-treated with liposomal chloroquine intraperitoneally 10 mg/kg before infecting them with C. neoformans 7 × 10 5 spores/animal. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Lipusu liposome chloroquine Pharmacokinetics and Biodistribution Study of Paclitaxel., Enhanced anticryptococcal activity of chloroquine in. Granulomatous nodules treated with plaquenilIs plaquenil toxicity reversiblePlaquenil oral side effectsPlaquenil and cancerHydroxychloroquine blindness We designed a liposome system co-encapsulating a chemotherapeutic drug doxorubicin hydrochloride, DOX and a typical autophagy inhibitior chloroquine phosphate, CQ at a weight ratio of 12 and investigated its drug resistance reversal mechanism. Journal of Liposome Research - Taylor & Francis. Chloroquine - Wikipedia. Preparation and in vitro evaluation of liposomal chloroquine.. Lipusu ®, also known as Paclitaxel Liposome for Injection, is composed of PTX that is solubilized in liposome that has been formed from lecithin and cholesterol, and is approved in China for clinical chemotherapy treatment. The third liposomal PTX preparation, Lipusu® paclitaxel liposome for injection, Luye Pharma Group, was developed by Sike Pharmaceutical Nanjing, Jiangsu, PRC. This preparation was approved by the State FDA of China. Lipusu® is the first commercially available PTX formulation to be marketed. Weekly and Every 3 Week Administration of Paclitaxel Liposome Injection in Metastatic Breast Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.