Prophylaxis for chloroquine resistant malaria

Discussion in 'International Pharmacy' started by Happyginger, 07-Mar-2020.

  1. Niviorniz Moderator

    Prophylaxis for chloroquine resistant malaria


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

    Plaquenil toxicity guideline Taking plaquenil and full body rash Sub for plaquenil Plaquenil stomach cramps

    Gozal D, Hengy C, Fadat G. Prolonged malaria prophylaxis with chloroquine and proguanil chloroguanide in a nonimmune resident population of an endemic area with a high prevalence of chloroquine resistance. Antimicrob Agents Chemother. 1991 Feb; 35 2373–376. PMC free article White NJ, Watt G, Bergqvist Y, Njelesani EK. Prophylaxis should begin 1 week before arrival in an endemic area, continue during the stay, and then continue for 4 weeks after leaving the area. Use For the prophylaxis of P falciparum and P vivax malaria infections, including prophylaxis of chloroquine-resistant strains of P falciparum US CDC Recommendations In areas where there is chloroquine-resistant malaria, either atovaquone/proguanil Malarone, mefloquine Lariam or doxycycline can be used for prophylaxis. Primaquine is a good alternative, but requires a G-6-PD screening blood test.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Prophylaxis for chloroquine resistant malaria

    Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC, Mefloquine Dosage Guide with Precautions -

  2. Laboratory synthesis of chloroquine
  3. For these reasons, and because chloroquine has not been found to have any harmful effects on the fetus when used in the recommended doses for malaria prophylaxis, pregnancy is not a contraindication to malaria prophylaxis with chloroquine or hydroxychloroquine.

    • Malaria ProphylaxisMalaria Site.
    • Malaria Travel & Health Guide, 2019 Online Book.
    • Chloroquine - LiverTox - NCBI Bookshelf.

    Oct 01, 2018 Chloroquine-Resistant Malaria Chloroquine phosphate tablets are not effective against Chloroquine-or hydroxyChloroquine-resistant strains of Plasmodium species see CLINICAL PHARMACOLOGY, Microbiology. Chloroquine resistance is widespread in P. falciparum and is reported in P. vivax. Before using Chloroquine for prophylaxis, it should be. Chloroquine resistance is widespread. Chloroquine should not be used for treatment of P. falciparum infections from areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed. Patients infected with a resistant strains of plasmodia should be treated with another antimalarial drug. Several medications are available for malaria prophylaxis. When deciding which drug to use, clinicians should consider the specific itinerary, length of trip, drug costs, previous adverse reactions to antimalarials, drug allergies, and medical history. For a thorough discussion of malaria and guidance for prophylaxis, see Chapter 4, Malaria.

     
  4. peter_850 New Member

    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Researchers will compare different malaria treatments and treatment schedules which include chloroquine therapy (weekly doses versus being dosed twice during pregnancy for 3 days each time) to the standard practice of preventive treatment intervals in pregnancy (with the drug sulfadoxine-pyrimethamine given twice during pregnancy). Chloroquine resistant vivax malaria in a pregnant woman on. Chloroquine for Malaria in Pregnancy RxWiki Chloroquine - Wikipedia
     
  5. max13 XenForo Moderator

    I have been on the plaquenil 200 mgm for about 4 months now. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil Uses, Dosage & Side Effects - Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus
     
  6. olegshel Moderator

    Plaquenil and Coumadin drug interactions - eHealthMe Drug interactions are reported among people who take Plaquenil and Coumadin together. This study is created by eHealthMe based on reports of 920 people who take Plaquenil and Coumadin from Food and Drug Administration FDA, and is updated regularly. eHealthMe has been monitoring drugs since 2008.

    Hydroxychloroquine - Wikipedia