They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. What is chloroquine aralen Chloroquine phosphate inverts Hydroxychloroquine false positive drug test Plaquenil pregnancy category c Plaquenil itself probably does not have a direct affect on your immune system - it is a DMARD and is not considered to be an immunosuppressant. However, many with active autoimmune diseases feel that they are not succeptible to many of the common viruses that they are exposed to - somewhat of a silver lining. Cannabis May Suppress Immune System. April 15, 2003 -- Cannabis may offer hope to people with autoimmune disorders such as lupus and rheumatoid arthritis. Cannabis seems to decrease inflammation in the body by suppressing certain parts of the immune system. Researchers are hoping this finding will lead to new treatments. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory pathways. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Does plaquenil suppress the immune system Does Plaquenil supress the immune system?, Cannabis May Suppress Immune System Oct findings of plaquenil maculopathy I've been on 400 mg plaquenil since last Dec 2007. My symptoms have been under the control. Some literatures recommended not to take this medicine while on AP. Others seemed to not worry about it. Interesting thing is “Plaquenil is an anti parasite medicine developed to treat malaria. Plaquenil - Road Back Foundation. Taking Plaquenil for Rheumatoid Arthritis. Is Plaquenil an immumo-suppressant? -. Examples include prednisone, methylprednisolone, Imuran, azathioprine, methotrexate, leflunomide, Arava, CellCept, mycophenolate, Rituxan, cyclophosphamide. Please note that hydroxychloroquine Plaquenil does NOT suppress your immune system and does not increase any risk for a more serious illness from COVID-19. Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree, because ‘overactivity’ of the immune system is what drives the illness. Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system.