Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine cancer clinical trial Is hydroxychloroquine teratogenicity Hydroxychloroquine sulphate 200mg side effects Plaquenil afecta los ojos Plaquenil toxicity first affects small areas of the retina between 5° and 15° from the fovea. Figures 2 and 3 show three patients at different stages of toxicity. Figure 2 bottom right shows a color display of normal mfERGs. The amplitude of the mathematically derived b-wave of the mfERG is displayed in a color scale. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. A list of medications to use with caution if you have macular degeneration. The AMDF is a 501c3 non-profit, publicly supported organization. Contributions are tax deductible to the extent allowed by law. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Macular society hydroxychloroquine Clinical Guidelines - The Royal College of Ophthalmologists, Hydroxychloroquine Plaquenil Toxicity and. 200 20 000 chloroquine Hydroxychloroquine is used widely for the treatment of systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatologic conditions. It is now being considered for new applications in diabetes mellitus, heart disease, and adjunct cancer therapy. Recommendations on Screening for Chloroquine and.. Medication Cautions in Macular Degeneration - AMDF. Rx Side Effects New Plaquenil Guidelines and More.. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Macular Society is the trading name of the Macular Disease Society. A charity registered in England and Wales 1001198, Scotland SC042015. 1123 Isle of Man. A company limited by guarantee, registered in England No. 2177039. Hydroxychloroquine is a drug increasingly used in the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders.