This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Plaquenil and psychosis Visual defects hydroxychloroquine Combination of sulfasalazine hydroxychloroquine and leflunomide for ra Map of malaria regions chloroquine resistance Chloroquine and Hydroxychloroquine Overdose Chloroquine Aralen®is commonly used for the treatment and prevention of malaria. Hydroxychloroquine, a constituent of chloroquine, is sold in the U. S. as Plaquenil® and is also utilized for its anti-malarial activity. Chloroquine, a well-known anti-malarial drug may be lethal when ingested in large amount. We report the case of a 45 year-old patient who ingested 10 g of chloroquine in a suicidal attempt, 3 h prior to presentation. Despite aggressive management, Chloroquine overdose must be treated quickly. You may be told to induce vomiting right away at home, before transport to an emergency room. Ask the poison control center how to induce vomiting in the case of an overdose. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine overdose fatal Chloroquine poisoning. Rapidly fatal without treatment. The BMJ, PDF Chloroquine overdose Hugues Lefort and Olga Maurin. Ibuprofen with plaquenilHydroxychloroquine lupus anticoagulantWikipedia hydroxychloroquine The only study in humans looking at severe chloroquine overdoses was done by Riou et al in 1988. 12 The criteria for severe chloroquine poisoning was an ingestion of 5 grams, which a retrospective study had determined to be an accurate predictor of a fatal outcome. They treated 11 prospective chloroquine overdose patients with immediate. Treatment of hydroxychloroquine overdose - ScienceDirect. Chloroquine PeaceHealth. Chloroquine Uses, Side Effects & Warnings -. Severe chloroquine overdose may cause convulsions, coma, shock, and respiratory or cardiac arrest. Quinidine-like cardiotoxicity may be seen, including sinoatrial arrest, depressed myocardial contractility, QRS- and/or QT-interval prolongation, heart block, and ventricular arrhythmias. These investigators examined the relation between plasma potassium concentration and the severity of poisoning. They retrospectively identified 191 consecutive cases of chloroquine overdose over six years, 12 percent of which proved fatal. Chloroquine is on the list of ‘two pills that can kill‘ toddlers. The worst case scenario is an ingestion of 310mg/15kg = ~21 mg/kg. In general 10mg/kg is considered toxic, with increasing mortality at doses 30mg/kg. In adults 5g or more is considered fatal unless life-saving interventions are performed.