Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Chloroquine phosphate and coral Plaquenil and gerd Atp quantification assay chloroquine HYDROXYCHLOROQUINE RETINOPATHY 1483 systemic lupus erythematosus, but none of the termina- tions were due to ocular toxicity. The low incidence of HCQ retinal toxicity has complicated the search for the best method for detecting such toxicity. Many different tests and screening sched- ules have been proposed, often without differentiating The risk of retinal damages is small with daily doses of up to 6.5 mg/kg ideal lean body weight. Exceeding the recommended daily dose sharply increases the risk of retinal toxicity. Significant risk factors for toxic retinopathy reported during long-term ≥5 years treatment with hydroxychloroquine include daily doses greater than 6.5 The aim of this study was to determine the proportion of patients treated with HCQ who develop retinal toxicity and the risk factors for the development of HCQ-induced retinal toxicity among Iranian patients. Retinal Toxicity, Hydroxychloroquine. The exact incidence and prevalence of HCQ-induced retinal toxicity is unknown. As the. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Incidence of retinal toxicity from plaquenil Despite Plaquenil dosing recommendations, retinal toxicity., Plaquenil Hydroxychloroquine Sulfate - Sanofi Chloroquine for discoid lupus Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible. Rx Side Effects New Plaquenil Guidelines and More - American.. Retinal Toxicity in Patients Treated With.. Hydroxychloroquine Plaquenil Toxicity and.. Focus on Eyes Long-term Plaquenil intake can affect your vision. Taking high doses or long-term treatment of Plaquenil, an anti-malaria drug used to treat lupus, can lead to vision problems. Sep 15, 2014 Although the drug has a relatively safe systemic profile, its use is associated with an increased incidence of macular toxicity––particularly if an individual has been on Plaquenil therapy for many years. 1,2 Specifically, a 2010 study indicated that the overall risk of Plaquenil macular toxicity increases by about 2% for every 10 to 15. Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body.