How chloroquine causes itch

Discussion in 'Generic Chloroquine' started by ddfeerrtui, 06-Mar-2020.

  1. regreg New Member

    How chloroquine causes itch


    Itch has many similarities to pain, and while both are unpleasant sensory experiences, their behavioral response patterns are different. Pain creates a withdrawal reflex, whereas itch leads to a scratch reflex.

    Hydroxychloroquine 200 mg ingredients Most common side effect of hydroxychloroquine

    The itching reactions caused by chloroquine or cowhage don't respond to anti-histamines. Certain opioids used to treat pain, such as morphine, can also cause a histamine-independent itch as a side. Lead researcher Diana Bautista collected a variety of substances that cause the itch reflex, including a plant called cowhage and the drug chloroquine, which often causes a persistent, all-over itch. The itch produced by chloroquine is so common that in some African countries 70 percent of the population has been affected by it. Investigators have used histamine along with another pruritogen, chloroquine, in an attempt to define the afferent nerve phenotype responsible for itch transduction in mice. Chloroquine is an anti-malarial drug known to evoked pruritus as one potential side-effect in humans.

    Pain and itch have very different behavioral response patterns. Unmyelinated nerve fibers for itch and pain both originate in the skin; however, information for them is conveyed centrally in two distinct systems that both use the same nerve bundle and spinothalamic tract.

    How chloroquine causes itch

    Cause of nonallergic itch identified -- ScienceDaily, Study suggests connection between itch and pain symptoms

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  5. Drugs that release histamine can cause itching. Example Opioids, Chloroquine. Cholinergic Urticaria. It is a skin rash appearing on thighs shortly after running, walking or taking hot shower that lasts upto an hour or two. One should avoid scratching, stop running in hot weather and use lukewarm shower.

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    PRURITUS or itch is a cutaneous sensation that leads to body scratching. Chloroquine is used both as an antimalarial drug and in the treatment of rheumatological disorders, such as rheumatoid arthritis and systemic lupus erythematosus. Dec 25, 2009 The itch receptors identified by Howard Hughes Medical Institute HHMI scientists belong to a family of proteins known as Mrg receptors. “We think that chloroquine causes itching primarily by binding to an Mrg receptor on nerve fibers in skin,” said Xinzhong Dong, the senior author on the study and an HHMI Early Career Scientist at Johns Hopkins University. Itch also known as pruritus is a sensation that causes the desire or reflex to scratch. Itch has resisted many attempts to be classified as any one type of sensory experience. Itch has many similarities to pain, and while both are unpleasant sensory experiences, their behavioral response

     
  6. EugSpb New Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. RA and Hydroxychloroquine How Effective is it for Rheumatoid. Hydroxychloroquine - Wikipedia Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria
     
  7. lik-link Guest

    Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). RA - what else can I try, now on methotrexate, have tried. What next if plaquenil doesn't work? - Sulfasalazine User Reviews for Rheumatoid Arthritis at
     
  8. gromul Guest

    Prednisone and Plaquenil question" Lupus Community. Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. I hope you can get off of it completely, or at least take a small maintenance dose. Take it very slow, tapering off, and if you have a reaction, severe fatigue, etc, talk to your doc, about tapering down even slower.

    Plaquenil Dosage Guide -