Chloroquine retrovirus production

Discussion in 'Chloroquine Phosphate' started by gavno20080, 20-Mar-2020.

  1. Rendel New Member

    Chloroquine retrovirus production


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Chloroquine is a weak base, commonly used in the treatment of malaria and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. 15-23 It is readily absorbed when administered by either oral or parenteral routes, 15-23 becoming highly concentrated in tissues such as the adrenal glands, liver, spleen and kidney 15-18. In this study, the effect of chloroquine on transduction and associated toxicity of baboon CD34 cells and a variety of cell lines was studied. Materials and Methods. Cell lines. To study the effects of chloroquine on retroviral transduction of cell lines, three cell lines were chosen Hela cells, D17 and 208 F cells.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine retrovirus production

    Treatment for AIDS and other retrovirus-caused diseases., Chloroquine could be used for the treatment of filoviral.

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  6. Consequently, chloroquine analogs inhibit the production of several cytokines, chemokines or mediators, whose excessive appearance contributes the severity of viral infections. Therefore, the inhibition of endosomal acidification by chloroquine analogs may become a potential therapeutic strategy for viral infections and associated pathologies.

    • Targeting endosomal acidification by chloroquine analogs as a..
    • EFFECT OF CHLOROQUINE ON TRANSDUCTION OF CELL LINES AND..
    • Blocking Type I Interferon Production A New Therapeutic..

    Proc. Natl. Acad. Sci. USA Vol. 90, pp. 8392-8396, September 1993 Cell Biology Productionofhigh-titer helper-free retroviruses by transienttransfection retroviral packaingcells/gene therapy Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Let's take inventory on the therapies that are being developed for the coronavirus epidemic. Here is a very thorough list of at Biocentury, and I should note that like Stat and several other organizations they're making all their Covid-19 content free to all readers during this crisis. I'd like to

     
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