Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Increase in malaria deaths after chloroquine failure Plaquenil main side effects Hydroxychloroquine is used to treat rheumatoid arthritis; discoid and systemic lupus erythematosus SLE. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits. The symptoms of second stage, early disseminated, Lyme disease can be difficult to attribute. Symptoms include severe fatigue, fever, pain, intermittent weakness and achiness of the muscles and joints, numbness in arms and legs, vision changes, and cognitive dysfunction such as short-term. Sep 13, 2019 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil lyme joint pain Taking Plaquenil for Rheumatoid Arthritis, Lyme Disease Symptoms Johns Hopkins Lyme Disease Research. Plaquenil inflammatory arthritisChloroquine onlinePlaquenil retinal toxicity dosage Plaquenil was great for the pain and swelling but did almost nothing for the fatigue. I actually have found nothing for fatigue. Of all the meds, Plaquenil was the best for me and helped the most, but some people don't tolerate it. Plaquenil for joint pain -. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil and pain" Rheumatoid Arthritis Community.. Jul 15, 2006 l have been taking plaquenil for 7 years now, at first it really helped me, l never had any side effect and l went into remission for 5 1/2 years with no pain, but unfortunately the pain started to come back last year, my RA doctor added methotrexate with my plaquenil and its been 8 months now and l haven't had any improvement in fact it is. Plaquenil and Joint pain - a study from real-world data. Summary Joint pain is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.