Why chloroquine is given in liver abscess

Discussion in 'Canadian Pharmacy' started by Adriano, 26-Feb-2020.

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    Why chloroquine is given in liver abscess


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    The objec­ tions to chloroquine often quoted are the studies of Wilmot et al. 2, 3 from Natal re­ porting a 20 to 25% recurrence rate of amoebic abscess in patients given 20 or 28 days of chloroquine. In 1962, we observed a recurrence of symptoms in 1 patient 3 months after completing a 3-week course of chloroquine. As discussed earlier, the incidence of amoebic liver abscess is much less in females. Surprisingly, on going through the literature, we have not come across any publication on "amoebic liver abscess during pregnancy". While viral hepatitis is so common during pregnancy, why is amoebic liver abscess so uncommon? G chloroquine phosphate 600 mg base orally once a day for 2 days, followed by 500 mg chloroquine phosphate 300 mg base orally once a day for at least 2 to 3 weeks Comments -Treatment is usually combined with an effective intestinal amebicide.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Why chloroquine is given in liver abscess

    Chloroquine C18H26ClN3 - PubChem, Amoebic Liver Abscess by Dr. O. P. Kapoor

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  5. Eight patients with amoebic liver abscesses in Cuba were treated with chloroquine. Some at least of them had been opened surgically; in 5 of the 8 cases typical parasites had been found in the matter obtained from the liver lesions. The total dosages of chloroquine used ranged from 121/2 to 15 gm.

    • Chloroquine for Amoebic Liver Abscess..
    • Chloroquine Dosage Guide with Precautions -.
    • Pyogenic and amebic liver abscess - Surgical. - NCBI Bookshelf.

    In treatment of amoebic liver abscess, chloroquine may be used instead of or in addition to other medications in the event of failure of improvement with metronidazole or another nitroimidazole within 5 days or intolerance to metronidazole or a nitroimidazole. Liver abscess has been recognized since Hippocrates circa 400 B. C. who speculated that the prognoses of the patients were related to the type of fluid within the abscess cavity 1. Although amebic liver abscess occurs more commonly on a worldwide basis, the pyogenic liver abscess predominates in the United States. Oct 15, 2019 In general, metronidazole, tinidazole, emetine, and dehydroemetine are active in invaded tissues; chloroquine is active only in the liver; tetracycline acts on the bowel wall; and diloxanide furoate, paromomycin, and iodoquinol are luminal agents only.

     
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