In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Is plaquenil hard on your eye sight hearing and memory Hydroxychloroquine sulphate side effects Chloroquine for research Chloroquine fda pregnancy category The previous ophthalmological examination had been made 3 years before and there was no sign of retinal involvement. A skin biopsy was performed and showed pigment deposition in superficial dermis with haemosiderin characteristics—Perls Prussian staining was positive for iron and Fontana-Masson staining was negative for melanin. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine-induced pigmentation Hydroxychloroquine-induced pigmentation in two patients with., Plaquenil Side Effects Common, Severe, Long Term - Fluoroquinolones hydroxychloroquinePlaquenil increased gasHydroxychloroquine 200 mg tab sanLong term effects hydroxychloroquine Skin pigmentation related to use of hydroxychloroquine starts out as a yellow brown to slate gray or black pigmentation on many areas of the body - especially the front of the shins but also the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Hydroxychloroquine-Induced Pigmentation in Patients With.. Prevalence and risk factors of hyperpigmentation induced by.. Pigmentation from heavy metal toxicity may be permanent; Iron can cause a dark brown pigmentation siderosis at the site of inadvertent subcutaneous injection; Excessive gold, previously used in the treatment of rheumatic diseases, can cause diffuse golden brown pigmentation; Ingested silver salts may induce a diffuse greyish pigmentation argyria Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication.