Hydroxychloroquine-induced pigmentation

Discussion in 'Canadian Pharmacy' started by Prozac2008, 29-Feb-2020.

  1. mind1er Moderator

    Hydroxychloroquine-induced pigmentation


    In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent.

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    The previous ophthalmological examination had been made 3 years before and there was no sign of retinal involvement. A skin biopsy was performed and showed pigment deposition in superficial dermis with haemosiderin characteristics—Perls Prussian staining was positive for iron and Fontana-Masson staining was negative for melanin. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ.

    Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended.

    Hydroxychloroquine-induced pigmentation

    Hydroxychloroquine-induced pigmentation in two patients with., Plaquenil Side Effects Common, Severe, Long Term -

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  6. Skin pigmentation related to use of hydroxychloroquine starts out as a yellow brown to slate gray or black pigmentation on many areas of the body - especially the front of the shins but also the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds.

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    Pigmentation from heavy metal toxicity may be permanent; Iron can cause a dark brown pigmentation siderosis at the site of inadvertent subcutaneous injection; Excessive gold, previously used in the treatment of rheumatic diseases, can cause diffuse golden brown pigmentation; Ingested silver salts may induce a diffuse greyish pigmentation argyria Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication.

     
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    This is not a list of all drugs or health problems that interact with chloroquine. Chloroquine Phosphate Page 2 HumbleFish Forum Chloroquine - Wikipedia Chloroquine Phosphate For Fish Food - Buy Chloroquine.
     
  8. Seobastiya Guest

    Compare Plaquenil vs Chloroquine - Head-to-head comparisons of medication uses, side effects, ratings, and more. Treats malaria and autoimmune conditions including rheumatoid arthritis and lupus. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs.

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