Had symtoms of malar rash, joint pain especially in hands, fatigue , dry eyes and dry skin . Had a biopsy of skin and confirmed cutaneous lupus. I was put on Plaquenil and for the past 8 years I have been fine with it . Now this year I have been having things pop up that are related to a low immune system. Aralen dosage for lupus Liver enzymes plaquenil Plaquenil and eye damage Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. The types of drugs that have been used to treat lupus include NSAIDs, corticosteroids and other immune system suppressing drugs, hydroxychloroquine, and the newest lupus drug, Benlysta. Lupus. A recent large study of people with cardiovascular disease found that hydroxychloroquine Plaquenil does not increase the risk of infection and methotrexate increases the risk of infection only slightly. The concern with immune suppression is that the virus could replicate more freely and cause more severe or extensive disease, says Dr. Winthrop. Does anybody have any input concerning taking Plaquenil for long term therapy ? Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack . I tried to only take 100 mg to see if it would make a difference but I started with terrible joint pain and fatigue so I am back on the 200 mg a day. Hydroxychloroquine immune suppressant Is Plaquenil a immunosuppressant drug ? Autoimmune., Lupus Medications and Treatments Plaquenil heartburnChloroquine drug resistancePlaquenil weight based dosingPlaquenil pregnancy category australiaRheumatoid arthritis medications hydroxychloroquine The number of patients taking immunosuppressive drugs for the management of autoimmune inflammatory conditions is increasing. The general practitioner needs to be active in preventing, monitoring and managing the adverse effects of these drugs even long after the treatment has ceased. Long-term management of patients taking immunosuppressive.. Coronavirus and Arthritis What You Need to Know.. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Unlike other DMARDs, Plaquenil does not suppress the immune system. It changes something within the cell to decrease the inflammation. I've been on it 6 months and my joints, fatigue and nose/mouth ulcers have improved. I've had one cold since then, which isn't more than usual for me. Anti-DNA antibodies exert their pathogenic effects through deposition as immune complexes in the kidney or through the recognition of cross-reactive antigens in the kidney, while in situ deposition of an immune complex composed of DNA, anti-DNA antibody and IgG in the renal tissue leads to the activation of the complement system and causes a.