Synthesis of chloroquine from 4 7-dichloroquinoline

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  1. alikim User

    Synthesis of chloroquine from 4 7-dichloroquinoline


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    Hydroxychloroquine high anion gap ketoacidosis Antimalarial hydroxychloroquine Mechanism of resistance to chloroquine

    Chloroquine is a member of the drug class 4-aminoquinoline. It works against the asexual form of malaria inside the red blood cell. Chloroquine was discovered in 1934 by Hans Andersag. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. The synthesis of various 4-aminoquinoline antimalarials may be achieved by nucleophilic reaction of 91 with desired amines. Scheme 2 outlines the preparation of chloroquine 3 and amodiaquine 8 starting from 4,7-dichloroquinoline 91 134–136. Ionic-Liquid-Promoted Palladium-Catalyzed Multicomponent Cyclocarbonylation of o-Iodoanilines and Allenes To Form Methylene-2,3-dihydro-1H-quinolin-4-ones. The Journal of Organic Chemistry 2007, 72 9, 3218-3222. DOI 10.1021/jo0624851.

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    Synthesis of chloroquine from 4 7-dichloroquinoline

    Chloroquine - ScienceDirect, Chloroquine - an overview ScienceDirect Topics

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  4. Plaquenil drug name
  5. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

    • Chloroquine C18H26ClN3 - PubChem.
    • A New Synthesis of Chloroquine Journal of the American Chemical Society.
    • In Vitro Antimycobacterial Activity of New 7-Chloroquinoline..

    Dichloroquinoline 86-98-6 route of synthesis, 4,7-Dichloroquinoline chemical synthesis methods, 4,7-Dichloroquinoline synthetic routes ect. +86-400-6021-666 [email protected] We report the synthesis and in vitro antimalarial activity of several new 4-amino-and 4-alkoxy-7-chloroquinolines carrying a linear dibasic side chain. Many of these chloroquine analogues have submicromolar antimalarial activity versus HB3 chloroquine sensitive and Dd2 chloroquine resistant strain of P. falciparum and low resistance indices were obtained in most cases. A New Synthesis of Chloroquine

     
  6. Kicker Guest

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Plaquenil - Lupus
     
  7. pavellift Moderator

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis.

    Fever - Symptoms and causes - Mayo Clinic