Plaquenil retinal toxicity dosage

Discussion in 'Canadian Online Pharmacy' started by guimplenchik, 15-Mar-2020.

  1. AMURSUIMI Well-Known Member

    Plaquenil retinal toxicity dosage


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Our data show that, although no hydroxychloroquine use is completely safe, the risk of retinal toxicity can be kept low with careful dosage adjustment and with shorter periods of use. However, the risk rises markedly with concurrent kidney disease, and the prevalence can exceed 50% with use above 5.0 mg/kg and with duration beyond 20 years. Of course the aim is avoid drug related retinal toxicity, which on ophthalmic examination, appears as the classic Bull’s eye change affecting the macula. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. Nov 12, 2019 Retinal toxicity is found among people who take Plaquenil, especially for people who are female, 40-49 old, have been taking the drug for 5 - 10 years, also take medication Arava, and have Osteoporosis

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Plaquenil retinal toxicity dosage

    Retinal Screening for Hydroxychloroquine Plaquenil Toxicity Retina., My Take on New Ocular Screening Guidelines for Plaquenil RheumNow.

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  7. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been.

    • Recommendations on Screening for Chloroquine and..
    • Will you have Retinal toxicity with Plaquenil - eHealthMe.
    • Retinal Physician - Hydroxychloroquine Maculopathy An..

    Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use. Risk for toxicity is less with 5.0 mg/kg real weight/day for hydroxychloroquine and 2.3 mg/kg real weight/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Plaquenil has replaced chloroquine because it produces less retinal side effects. Aside from its initial intended use, it has been also used for the management of rheumatoid arthritis, systemic lupus erythematosus and several other connective tissue disorders 1. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure.

     
  8. sever170276 Moderator

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Hydroxychloroquine Uses, Dosage & Side Effects - Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings. Plaquenil Side Effects - GoodRx
     
  9. geg_MOPO3 Well-Known Member

    Hydroxychloroquine Plaquenil Eye exam fax-back form Hydroxychloroquine Plaquenil Eye exam fax-back form Why do I need an eye exam? An eye exam can check for eye problems even if your vision seems fine. If you take hydroxychloroquine hahy-drok-si-KLOHR-uh-kwin Plaquenil all ophthalmology offices have the equipment to PLAK-wuh-nil, you have a higher risk of developing an eye problem

    Starting Plaquenil BEFORE Eye Exam? - Scleroderma - Inspire