One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine sul tabs 200 mg Plaquenil and celexa interaction Hydroxychloroquine sulphate side effects Alternative for plaquenil Download PDF. Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine Plaquenil. 1 The most common symptoms of this side effect are difficulty reading or seeing words, letters, or parts of objects may be missing or blurred vision. The changes are reversible if this is detected early. How to minimize the side-effects of Plaquenil Patients should get their eyes checked by an eye doctor every year. Aug 29, 2014 This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The side effect that is of greatest concern is retinal toxicity. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil adverse effect on retina Plaquenil Side Effects Common, Severe, Long Term -, Plaquenil – RheumInfo Hydroxychloroquine sulphate tabletsrheumatoid arthritisDiamondback chloroquine phosphate Medications that can Affect the Eye or Visual System. If the listing of medication side effects is reviewed in a medication package insert or in a publication such as the PDR Physicians Desk Reference, side effects such as "blurred vision" and "eye redness" are commonly mentioned. Medications that can Affect the Eye or Visual System. The Risk of Retinal Toxicity with Plaquenil. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects.