The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient’s QT interval shortened. What does plaquenil look like Retinal deposits plaquenil Neuropathy caused by plaquenil Make sure your doctor knows if you had a heart rhythm problem such as QT prolongation. This medicine may cause muscle and nerve problems. Check with your doctor right away if you have muscle weakness, pain, or tenderness while using this medicine. Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. Hydoxychloroquine HCQ is widely used for the treatment of rheumatoid arthritis RA and systemic lupus erythematosus SLE with a side-effect profile including myopathy and cardiotoxicity. Acute HCQ poisoning has been reported to cause a prolonged QT interval, hypokalaemia and a prolonged QRS complex. WebMD provides information about interactions between Azithromycin Oral and qt-prolonging-agents-hydroxychloroquine. The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used. Hydroxychloroquine qt prolongation Risks of Hydroxychloroquine - Medsafe, Long QT and Hydroxychloroquine; A Poorly Recognised. Lc3 aging gapdh chloroquine heartPlaquenil usoPlaquenil toxicity first screenin QT Interval prolongation Hydroxychloroquine has the potential to prolong the QTc interval in patients with specific risk factors. Hydroxychloroquine should be used with caution in patients with congenital or documented acquired QT prolongation and/or known risk factors for prolongation of the QT internal such as • advanced age, DATA SHEET 1 PRODUCT NAME 2 QUALITATIVE AND QUANTITATIVE.. Interactions between Azithromycin Oral and qt-prolonging.. CredibleMeds Home. Of the documented medications known to cause QT interval prolongation hydroxychloroquine HCQ is extremely rare in the literature. HCQ is an antimalarial that has become the cornerstone for treatment of systemic lupus erythematosus SLE 9. Drugs associated with QT Prolongation, QTc prolongation. LITFL Further Reading. ECG Library Basics – Waves, Intervals, Segments and Clinical Interpretation; ECG A to Z by diagnosis – ECG interpretation in clinical context PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects.