Chloroquine for malaria prophylaxis

Discussion in 'Canada Drugs' started by zxcv, 17-Mar-2020.

  1. sevp New Member

    Chloroquine for malaria prophylaxis


    Information in these tables is updated regularly.4. Several medications are available for chemoprophylaxis. When deciding which drug to use, consider specific itinerary, length of trip, cost of drug, previous adverse reactions to antimalarials, drug allergies, and current medical history.

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    Summary. Aralen is the brand name for the generic drug chloroquine, an anti-malaria drug used to treat malaria and amebiasis infection that's spread outside of the intestines. Dosage, drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to taking this drug. No harmful effects on the fetus have been observed when chloroquine or hydroxychloroquine are used in the recommended doses for malaria prophylaxis. 2 Observational data 5, 6 amounting to more than 1000 exposures and 1 double-blind randomized-controlled trial 7 N = 951 have evaluated the use of chloroquine at various stages of pregnancy for the prevention of malaria and have not identified any teratogenicity or other adverse events. As a result, this agent is considered safe for use in. Chloroquine is currently administered orally when used as a prophylaxis for malaria, as well as for the treatment of chronic autoimmune diseases. For malaria prophylaxis, 500 mg is typically administered orally two weeks before, during, and up to 8 weeks after exposure to an endemic area, taken as a weekly dose.

    This risk estimate is based largely on cases occurring in US military personnel who travel for extended periods of time with unique itineraries that likely do not reflect the risk for the average US traveler.6. All travelers should seek medical attention in the event of fever during or after return from travel to areas with malaria.5.

    Chloroquine for malaria prophylaxis

    Chloroquine - LiverTox - NCBI Bookshelf, Prophylactic use of antimalarials during pregnancy

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  4. There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women; usage during pregnancy should be avoided except in prophylaxis or treatment of.

    • Aralen, Chloroquine phosphate chloroquine dosing..
    • Chloroquine - StatPearls - NCBI Bookshelf.
    • Chloroquine - FDA prescribing information, side effects..

    Both adults and children should take one dose of chloroquine per week starting at least 1 week before. traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 300mg base 500mg salt. Chloroquine, a 4-amino-quinoline, has been the backbone of antimalarial therapy and prophylaxis for 50 years. The incessant spread of resistance to chloroquine by P. falciparum is leading to a resurgence of malaria in most endemic areas. Considerations when choosing a drug for malaria prophylaxis Recommendations for drugs to prevent malaria differ by country of travel and can be found in Malaria Information by Country. Recommended drugs for each country are listed in alphabetical order and have comparable efficacy in that country.

     
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