Estrogen use should be discontinued unless its need outweighs its adverse effects on porphyrin metabolism. After achievement of remission, estrogen therapies may be cautiously reinstituted; however, the duration of remissions may be shortened. Does plaquenil cause bile malabsorption Plaquenil dosage sjogren& 39 Hydroxychloroquine oral tablet is used for short-term treatment of malaria, but it may be used for long-term treatment of lupus or rheumatoid arthritis. Hydroxychloroquine comes with risks if you. CONCLUSIONS Hydroxychloroquine, 100 mg twice weekly, is as effective and safe as phlebotomy in patients with PCT, although noninferiority was not established. Given these results, higher-dose regimens of hydroxychloroquine, which have more side effects, do not seem justified. Usual Adult Dose for Rheumatoid Arthritis. -Initial dose 400 to 600 mg 310 to 465 mg base orally once a day to optimum response usually 4 to 12 weeks -Maintenance dose 200 to 400 mg 155 to 310 mg base orally once a day Dose adjustment The dose may need to be reduced temporarily if adverse side effects occur; If symptoms recur, re-treatment can restore remissions. Remissions may last from several months to many years. Low-dose hydroxychloroquine role in porphyria Is Hydroxychloroquine As Effective As Phlebotomy for Porphyria Cutanea., Low-dose hydroxychloroquine is as effective as phlebotomy in treatment. Hydroxychloroquine rheumatoid arthritisMacular thinning and plaquenil Role of delta-aminolevulinic acid in the symptoms of acute porphyria. Grady JJ, Freeman DH Jr, et al. Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with. Which medications should be avoided by patients with.. Hydroxychloroquine Dosage Guide with Precautions -. Low-Dose Hydroxychloroquine is as Effective as Phlebotomy.. Porphyria Cutanea Tarda and Polymorphous Light Eruptions. Has been used in treatment of porphyria cutanea tarda†. 114 116 117 See Patients with Psoriasis or Porphyria under Cautions. Has been effective in some cases when used in the treatment of polymorphous light eruptions†. Hydroxychloroquine Sulfate Dosage and Administration Administration Iron chelators are less effective than phlebotomy or low dose hydroxychloroquine or chloroquine in treating individuals with PCT. However, these drugs may play a role in treating affected individuals in whom the use of the two front-line therapies is not possible, such as individuals with end stage renal disease who are on hemodialysis. Porphyria cutanea tarda PCT is an iron-related disorder that results from reduced activity of hepatic uroporphyrinogen decarboxylase. Treatment options include phlebotomy or low doses of hydroxychloroquine.