Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Incidence of alopecia with plaquenil Chloroquine paludisme Atg3 chloroquine and aging Plaquenil dementia Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day. Regarding hydroxychloroquine levels and lupus activity, Costedoat- Chalumeau et al measured whole blood levels in 143 individuals taking a standard dose of 400 mg per day and found a lower hydroxychloroquine level in those with active disease and that lower baseline levels were predictive of disease flare. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Close monitoring for evidence of methotrexate toxicity should be done in patients receiving this combination, especially in those with reduced renal function. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine lupus dose Protecting your eyesight when taking Plaquenil Lupus., Hydroxychloroquine Blood Levels in SLE Clarifying dosing. Plaquenil and cancer risk Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. Hydroxychloroquine Plaquenil. Plaquenil hydroxychloroquine sulfate dose, indications.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Mar 17, 2019 Hydroxychloroquine dosing information. Usual Adult Dose for Malaria Treatment of the acute attack 800 mg 620 mg base followed in 6 to 8 hours by 400 mg 310 mg base, then 400 mg 310 mg base once a day for 2 consecutive days; alternatively, a single dose of 800 mg 620 mg base has also been effective Hi Tilcara. Here is some information about this unfortunate side effect from 'The Lupus Encyclopedia'; "One of the potential long-term side effects of using anti-malarial medications such as hydroxychloroquine, chloroquine, and quinacrine is the development of dark-coloured patches on the skin. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments.