In general, it's important to mention this to your prescriber. Hydroxychloroquine (Plaquenil and generics) can itself cause fatigue in some users, it can interrupt sleep patterns (especially by causing more vivid dreams) which in turn makes one more tired. Plaquenil and bipolar Plaquenil monograph Aralens phosphate Is anyone taking Plaquenil and if so, do you find it works for fatigue. Should I just bite the bullet and give it a whirl. I should mention that I believe many of my aches and pain is related to the fact that I am obese especially in hips/knees. I imagine this plays a part in how tired I am at times. I started on the Plaquenil a little over a week ago. Not much in the way of side effects. Some minor stomach stuff but that could be normal and not related to the Plaquenil. I started at 200mg and increased to 400mg after a week. Andie213, my fatigue has been frustrating for me as well. But it seems as though there is more recognition of Sjögren’s as being responsive to many of the same meds used for other autoimmune disorders. What I have noticed is that plaquenil seems to be diagnosed when there is ongoing fatigue and/or joint pain. I know that for me, it made a huge difference in terms of fatigue. This is especially true in those individuals with G6PD deficiency. The drug can also lower blood counts (red cell, white cells and others too) which in turn can cause fatigue. Plaquenil fatigue Plaquenil - Uses, Side Effects, Interactions -, Experiences taking Plaquenil for Fatigue and Muscle Pain. Hydroxychloroquine and edemaHydroxychloroquine lupus nephritis May 23, 2016 Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Ask the Expert Plaquenil and Sjögren’s. Plaquenil - General - Sjogren's Syndrome Support. Extreme fatigue on Plaquenil? lupus. May 25, 2010 I've never heard of anyone having fatigue from plaquenil since I've been on these forums. Usually, auto immune diseases and the conditions that go with them such as anemia and vitamin deficiencies cause the fatigue. In other cases, the fatigue can be caused by another condition, such as anemia or depression. Fatigue can also be a side effect of medication. If fatigue hinders you, there are ways you can try to increase your energy with lupus. This article offers five key ways to cope with fatigue and boost your energy levels. Summary Number of reports submitted per year Time on Plaquenil when people have Fatigue * Gender of people who have Fatigue when taking Plaquenil * Age of people who have Fatigue when taking Plaquenil * Conditions people have * Pain 264 people, 6.25% Osteoporosis. Other drugs people.