It's the first drug most doctors prescribe after you’re diagnosed. It will help ease symptoms like joint pain, fatigue, redness, and swelling. Hydroxychloroquine 200 mg dosage Plaquenil route Hydroxychloroquine sulfate usp 200 mg Mechanism of action hydroxychloroquine Background Lichen planopilaris is an inflammatory cicatricial alopecia, and its management is a challenge for dermatologists. We aimed to compare the efficacy of methotrexate and hydroxychloroquine on refractory lichen planopilaris. Methods In a randomized clinical trial, 29 patients were randomly allocated to receive either 15 mg methotrexate/week or 200 mg hydroxychloroquine twice a day. Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. Methotrexate interrupts the process that causes RA inflammation, which damages your joints and organs over time. It may also help prevent damage to your organs and joints. If hydroxychloroquine was ineffective would it be effective with methotrexate Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center, Hydroxychloroquine Side-effects, uses, time to work Fang and hydroxychloroquine screeningPlaquenil pronouncePlaquenil and mood changesHydroxychloroquine retinopathy pathogenesis In hydroxychloroquine group, only erythema P = 0.004 showed significant improvement. Conclusions Methotrexate was more effective than hydroxychloroquine in treating refractory lichen planopilaris. Clinical efficacy and safety of methotrexate versus hydroxychloroquine.. Effects of methotrexate and hydroxychloroquine combination therapy vs.. Is hydroxychloroquine effective in treating primary.. The study is based on hydroxychloroquine sulfate and methotrexate sodium the active ingredients of Plaquenil and Methotrexate, respectively. Other drugs that have the same active ingredients e.g. generic drugs or brand names are also considered. In patients with rheumatoid arthritis, combination therapy with methotrexate, sulfasalazine, and hydroxychloroquine is more effective than either methotrexate alone or a combination of. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction.