I had some of the usual problems with the upset stomach at the beginning but it got better with time. Over the last 8-10 weeks I have noticed that I have been getting very dark circles under my eyes which starts at the inner corner of my eye. Plaquenil and tb test Is aralen safe for pregnancy Skin pigmentation related to use of hydroxychloroquine starts out as a yellow brown to slate gray or black pigmentation on many areas of the body - especially the front of the shins but also the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. How common is it? Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. I thought it was because I was not doing very well for a couple of weeks.... When I looked closer the skin is a little red with a bluish black color like a bruise. Gray nails and plaquenil Hydroxychloroquine-Induced Pigmentation in Patients With Systemic Lupus., Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil pediatric doseChloroquine phosphate 250 mg side effectsPlaquenil toxicity macular octCost of plaquenil at walmart pharmacy Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Skin Discoloration and Plaquenil - Arthritis Information. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Erythema Dyschromicum PerstansAshy Dermatosis- Causes.. Nail abnormalities are common, affecting the shape, thickness, or color of the nails. In this article, we look at possible abnormalities that affect the fingernails or toenails, with a picture. This Home Depot guide explains all that you need to know about Nails, Design, Types and Techniques to accomplish the high-quality work you expect from yourself. Apr 10, 2019 Plaquenil is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay.